The Weight Loss Lie Dave Asprey Says Is Keeping You Stuck

DATE

Jan 8, 2026

GUEST

Dave Asprey

MINUTES

66:35
Min

GUEST

Dave Asprey

About the episode

In this episode of BioHack-It, I sit down with Dave Asprey, founder of Bulletproof and the creator of the biohacking movement, to challenge some of the most dangerous health advice we’ve all been taught.

Dave explains why “eat less and work out more” is bad advice, how your nervous system and mitochondria actually control weight, energy, and focus, and why willpower almost always fails. We talk about chronic fatigue, inflammation, trauma, and the biological reasons so many people feel anxious, exhausted, and stuck despite doing everything “right.”

We also dive into supplements, why modern food is nutrient depleted, the truth about biohacking for women, psychedelics and altered states, relationships, boundaries, longevity tools like gene therapy and stem cells, and what real optimization actually looks like.

This conversation is about energy, freedom, and building a body and mind that actually work for you.

Topics include: biohacking, weight loss, metabolism, mitochondria, nervous system regulation, supplements, longevity, psychedelics, trauma healing, relationships, boundaries, fasting, nutrition, consciousness, Dave Asprey.

Chapters:

00:00- Intro 

01:45 Dave’s health crisis and why nothing worked

04:10 The weight loss lie keeping people stuck

06:00 Mitochondria, energy, and fight or flight

09:00 How to calm your nervous system for real

12:00 Psychedelics, breathwork, and altered states

15:40 Trauma, boundaries, and cutting off toxic people

19:20 Relationships, dating, and emotional regulation

22:30 Discipline vs freedom and “extreme laziness”

26:00 Supplements that actually matter

31:00 Why modern food has fewer nutrients

36:30 Biohacking myths and industry mistakes

41:10 Gene therapy, stem cells, and longevity tech

47:30 Women, intuition, and mitochondrial health

52:00 Eastern medicine, consciousness, and wisdom

58:30 Final advice for energy, health, and freedom

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